Andrographolide : The Fantastic herb compound
"Andrographolide is a diterpene lactone and a major active ingredient found in the traditional herb Andrographis paniculata. Research studies from both within Thailand and abroad found that the compound relieves fever, exhibits anti-inflammatory and anti-viral properties, and has a bitter taste. Currently, Andrographis paniculata is widely used across Thailand, either for its leaves and other parts or its crude extracts in pellet or capsule form. However, the capsule form contains around 1.38-3.21% of Andrographolide, depending on where the herb is grown. As this compound is water insoluble, its absorption is limited to 2.67%, requiring individuals to consume three to four capsules each time, three to four times per day, totaling 9-16 capsules per day or an equivalent of 180 mg of Andrographolide per day.
Nanoemulsion : The game-changing innovation
Nanoemulsion technology has been used in a variety of products for quite some time, be it in cosmetics or pharmaceuticals, but it has not been used to develop Andrographolide in this form yet. Most of the available research tend to focus on the medicinal properties of Andrographolide in its powdered form.
During the Nanoemulsion process in the laboratory, there were several challenges, such as ensuring the consistency of particles smaller than 100 nanometers and maintaining the stability of the solution. In conducting experiments, it is important to identify the right type and amount of solution as well as to adjust the pH levels to prevent oxidation and harmful levels of acidity. The taste must also be modified to decrease the bitterness of Andrographolide and to cater to all ages.
In order to transfer the Nanoemulsion process from the lab to the factory setting, the team had to modify the machinery to meet the necessary standards. We use the ultrasonic Homogenizer at 60,000 hertz and the high-speed homogenizer that can reach up to 10,000 rounds per minute to ensure the quality and consistency of the manufacturing process.
The World's First Ever Andrographolide Nanoemulsion
Andrographolide has been further developed with medical technology and features in several research studies from abroad. The Lily Pharma team has researched and developed the world's first Andrographolide Nanoemulsion, which helps increase absorption by more than six times, thus requiring only a small amount while resulting in very high efficacy. This also reduces the risk of an overdose from the consumption of herbal medicine in its regular form. The overall process applies knowledge and technology backed by strong research to advance the quality of healthcare products for people all around the world.
